![]() This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Data for this project are available at NCBI under BioProject ID PRJNA525828.įunding: RM received grants from The Monica Lester Charitable Trust and The Elias, Genevieve and Georgianna Atol Charitable Trust. Received: NovemAccepted: JPublished: July 9, 2020Ĭopyright: © 2020 Leite et al. PLoS ONE 15(7):Įditor: Simon Clegg, University of Lincoln, UNITED KINGDOM ![]() (2020) The duodenal microbiome is altered in small intestinal bacterial overgrowth. ![]() Future research may elucidate host-microbiome interactions underlying these symptoms in SIBO patients.Ĭitation: Leite G, Morales W, Weitsman S, Celly S, Parodi G, Mathur R, et al. non-SIBO subjects, coupled with an altered Proteobacterial profile that correlates with symptom severity. Duodenal samples from SIBO subjects had 4x10 3-fold higher counts than non-SIBO subjects when plated on MacConkey agar (P10 3 CFU/mL cutoff for the definition of SIBO, and also reveal specific overgrowth of Proteobacteria in SIBO vs. Using the recently-redefined cutoff for SIBO of >10 3 colony forming units per milliliter (CFU/mL), 42 SIBO and 98 non-SIBO subjects were identified. Therefore, we aimed to determine and compare the duodenal microbiome composition in SIBO and non-SIBO subjects, using duodenal aspirates from subjects undergoing standard-of-care esophagogastroduodenoscopy without colon preparation. Moreover, existing studies of microbiome alterations in SIBO have utilized stool samples, which are not representative of the entire gastrointestinal tract. Small intestinal bacterial overgrowth (SIBO) is highly prevalent and is associated with numerous gastrointestinal disorders, but the microbes involved remain poorly defined. ![]()
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